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Pharmacokinetics and pharmacodynamics of the nucleoside sparing dual regimen containing rilpivirine plus darunavir/ritonavir in treatment-naive HIV-1-infected individuals

期刊: HIV CLINICAL TRIALS, 2018; 19 (1)

Background: We aimed at investigating the antiviral activity and the pharmacokinetics of the dual antiretroviral (ARV) combination of rilpivirine plus......

JIF:2.09

Paritaprevir/ritonavir/ombitasvir plus dasabuvir in HIV/HCV-coinfected patients with genotype 1 in real-life practice

期刊: HIV CLINICAL TRIALS, 2018; 19 (1)

Background: Data on the efficacy, safety, and concomitant use with other drugs of the combination ritonavir-boosted paritaprevir/ombitasvir plus dasab......

JIF:2.09

False-positive HIV diagnoses: lessons from Ugandan and Russian research cohorts

期刊: HIV CLINICAL TRIALS, 2018; 19 (1)

Background: Research studies rely on accurate assessment of entry criteria in order to maintain study integrity and participant safety, however, chall......

JIF:2.09

Implementation of a prospective pregnancy registry for antiretroviral based HIV prevention trials

期刊: HIV CLINICAL TRIALS, 2018; 19 (1)

Background: Safety data on pregnancy and fetal outcomes among women in HIV prevention trials are urgently needed to inform use of effective antiretrov......

JIF:2.09

Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a Multidisciplinary team

期刊: HIV CLINICAL TRIALS, 2018; 19 (1)

Objectives: Interactions between antiretroviral treatment (ART) and comedications are a concern in HIV-infected patients. This study aimed to determin......

JIF:2.09

Rosuvastatin and atorvastatin preserve renal function in HIV-1-infected patients with chronic kidney disease and hyperlipidaemia

期刊: HIV CLINICAL TRIALS, 2018; 19 (3)

Background:Hyperlipidaemia is a risk factor for the progression of chronic kidney disease (CKD), which is a frequent comorbidity in patients with HIV-......

JIF:2.09

A multi-site community randomized trial of community health workers to provide counseling and support for patients newly entering HIV care in rural Ethiopia: study design and baseline implementation

期刊: HIV CLINICAL TRIALS, 2018; 19 (3)

Background: Although HIV therapy is delivered to millions globally, treatment default (especially soon after entering care) remains a challenge. Commu......

JIF:2.09

Design of a randomized controlled trial of zinc supplementation to improve markers of mortality and HIV disease progression in HIV-positive drinkers in St. Petersburg, Russia

期刊: HIV CLINICAL TRIALS, 2018; 19 (3)

Background: Russia continues to have an uncontrolled HIV epidemic and its per capita alcohol consumption is among the highest in the world. Alcohol us......

JIF:2.09

Raltegravir versus lopinavir/ritonavir for treatment of HIV-infected late-presenting pregnant women

期刊: HIV CLINICAL TRIALS, 2018; 19 (3)

Background: Late-presenting pregnant women pose a challenge in the prevention of HIV-1 mother-to-child-transmission. We compared the safety and effica......

JIF:2.09

PRO 140, a monoclonal antibody targeting CCR5, as a long-acting, single-agent maintenance therapy for HIV-1 infection

期刊: HIV CLINICAL TRIALS, 2018; 19 (3)

Background: PRO 140 is a humanized monoclonal antibody targeting CCR5 with potent antiviral activity in patients with CCR5-tropic HIV-1 infection. In ......

JIF:2.09

The effect of switching protease inhibitors to raltegravir on endothelial function, in HIV-infected patients

期刊: HIV CLINICAL TRIALS, 2018; 19 (2)

Objective: Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may......

JIF:2.09

Evaluation of epidemiological, clinical, and laboratory features and mortality of 144 HIV/AIDS cases in Turkey

期刊: HIV CLINICAL TRIALS, 2018; 19 (2)

Background: The number of HIV/AIDS cases in Turkey is increasing rapidly, as is the number of cases worldwide. The aim of this study is to evaluate th......

JIF:2.09

New design, development, and optimization of anin-house quantitative TaqMan Real-time PCR assay for HIV-1 viral load measurement

期刊: HIV CLINICAL TRIALS, 2018; 19 (2)

Background: Viral load measurement is commonly applicable to monitor HIV infection in patients to determine the number of HIV-RNA in serum samples of ......

JIF:2.09

Durability and tolerability of first-line regimens including two nucleoside reverse transcriptase inhibitors and raltegravir or ritonavir boosted-atazanavir or -darunavir: data from the ICONA Cohort

期刊: HIV CLINICAL TRIALS, 2018; 19 (2)

Background: We aimed to mimic the ACTG 5257 trial, comparing raltegravir (RAL), ritonavir-boosted atazavavir (ATV/r) and ritonavir-boosted darunavir (......

JIF:2.09

Use of next-generation sequencing in the CHAT study (acute HCV in HIV): effect of baseline resistance-associated NS3 variants on treatment failure

期刊: HIV CLINICAL TRIALS, 2018; 19 (2)

Background: The epidemic of acute HCV infection among HIV-infected men who have sex with men (MSM) is ongoing. Transmission of drug-resistant variants......

JIF:2.09

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